- Originally, one episode had a scene where Fry pulls down his pants and moons the business magnate Mom (of Mom's Friendly Robots). Her original dialogue was, "You call that an anus?", but it only appeared in closed captioning and was redubbed with "You call that a pressed ham?".
- Cartoon Network has censored the Professor's favorite expletive, "Sweet Zombie Jesus" on at least two occasions, removing the Jesus.
- The series was cancelled after season 5, but was revived several years later on a different network. First, the 4 direct-to-DVD movies that had been made following the cancellation were split into 4 episodes each and shown as 16 episodes forming season 6. The "season 6" listed here was shown as season 7, and the "season 7" listed here was shown as season 8. After that, in syndication and some streaming services like Netflix and Hulu, the split-up movies were still labelled as season 6, but the following 2 seasons were themselves split into 4 seasons of 13 episodes each, and called seasons 7 through 10. Each of the 4 parts split from a single movie had its own credits with unique features, such as the 1930s cartoon and the slogan at the end of the opening credits, were new and different for each episode.
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