- Was allegedly the original choice to play Tony Soprano in the HBO series The Sopranos (1999) but turned the role down.
- Son of Maria Johannes (Brendel) (secretary) and Gedio "Eddie" LaPaglia (auto mechanic). His father was from Bovalino, Province of Reggio Calabria, Italy. His mother was Dutch.
- He is part owner of an Australian Soccer club called Sydney FC (Football Club)
- Although often cast as New York tough guys, few people know that he was actually born and raised in Australia. He has said that the only internationally successful Australian actor at the time he began acting was Mel Gibson, who had lost his Australian accent, so he did the same. Today, looking at all the hot young Australian actors who have kept their native accents but can use other dialects in their films, he says he regrets having dropped his accent.
- Filmed scenes playing as Chicago gangster Al Capone for the 2001 Tom Hanks drama Road to Perdition (2002), but all the scenes were cut out.
- Plays in goal for Hollywood United Football Team.
- Last name is pronounced La-Pahl-ya.
- Older brother of actor Jonathan LaPaglia and Michael LaPaglia.
- Won Broadway's 1998 Tony Award as Best Actor (Play) for a revival of Arthur Miller's "A View from the Bridge." He starred opposite Allison Janney, who played his wife and who was also nominated for a Tony. They each also won Drama Desk awards for their performances.
- Welcomed daughter, with Gia Carides, named Bridget born January 2003.
- He has his date of birth tattooed on his left forearm in Roman Numerals: I XXXI MCMLIX.
- Starred with Debi Mazar in So I Married an Axe Murderer (1993) as a love interest, then again in Empire Records (1995) as a love interest yet again.
- Listed as one of twelve "Promising New Actors of 1991" in John Willis' Screen World, Vol. 43.
- Brother-in-law of Ursula Brooks, former brother in law of Danielle and Zoe Carides.
- Current partner Alexanda Henkel.
- Born on exactly the same date as Kelly Lynch.
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