When Sheldon spends a few days at the hospital, he turns out to be the world's worst patient. Missy gets a taste of what it would be like if she didn't have a twin.
Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis' colleague, Dr. Linkletter, flirts with Meemaw, and Georgie is heartbroken when he learns Veronica has a boyfriend.
Sheldon and Dr. Sturgis have their first fight when Dr. Sturgis marks an answer wrong on Sheldon's test; Mary takes over for Pastor Jeff when he's out sick.
Sheldon's boycott of his favourite bread company goes out of control. Meanwhile, Georgie tries to console Veronica after breaking up with her boyfriend.
Sheldon gets inspired by his hero Albert Einstein and tries to play violin. Mary thinks that she is pregnant and goes to buy pregnancy test with Meemaw.
Sheldon moves in with Dr. Sturgis for the weekend to see what it's like in college and a lonely Mary tries to bond with the other Coopers during Sheldon's absence.
The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.
Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Meemaw learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.
Without Dr. Sturgis' university class, Sheldon must find a new way to stay academically challenged; Mary helps Pastor Jeff avoid temptation with his girlfriend.
Sheldon takes matters into his own hands when Meemaw refuses to drive him to a lecture; Georgie tries to impress Veronica with his new business venture.
Sheldon is forced to take a break from science when his new obsession with "The Lord of the Rings" leads to an unhealthy habit. Also, Missy asks George Sr. to teach her how to play catch.
Sheldon starts an internet flame war, and Missy stands up to the boys on her baseball team. Also, Meemaw is unhappy when George Sr. spends time with her new boyfriend.
The University makes George Sr a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Meemaw's new boyfriend and Mary is determined to rid her home of greed.