A Chinese mafia that trades human organs into the US, arrives at Naco seeking to lay down roots in the town. Naco is shaken up by the arrival of Natividad, the square's new drug lord who very soon makes new friends and enemies.
Güevín is kidnapped by Natividad who, in exchange, demands that Jenny be hand over in the next 24 hours if they don't want their friend to die. Gama and Morris go to look for Jenny to Las Vegas and find her partying with singer Cristian Castro.
"El Reverendo", Gamaliel's eldest brother and Olga's husband, has escaped from jail and arrives in town to spread terror. Morris starts a new relationship with Wendy, Natividad's daughter, who has recently arrived from the US.
Gamaliel and Morris take Scott's ashes to the US to throw them into the ocean. Everything complicates when Gama is kidnapped by members of the Ku Klux Klan and Morris has to go to a lot of trouble to rescue him.
El Reverendo becomes international news, after he kills three cops who tried to capture him, putting the Municipal Councillor in a tight spot. The army is about to intervene but Natividad tries to solve the conflict.
The Municipal Councillor is elected as candidate for state Governor and marries Jenny. Cristian Castro performs at their wedding and ends up seducing El Muerto's girlfriend. Enraged, the hitman tries to get back at the singer and Gama and Morris will have to come to his rescue.
Some dolphin traffickers capture two specimens in Mexican waters and hire El Faraón to take them to the USA. A rights activist couple goes after them and ask Gamaliel and Morris for their help.
Gama and Morris go to New York and run into Master Lama, who turns out is still alive and has become a self proclaimed end-of-the-world prophet. Gama and Morris take him back to Naco where Lama ends up creating a sect.
A retired marine pays Morris a visit to give him a memento from his brother Scott and seizes the opportunity to smuggle arms in the area. Natividad decides to run for Municipal Councillor ; Gama and Morris have a bad feeling about a grim future approaching the town.
A journalist threatened to death arrives at Naco to cross the border, not without first exposing the relationship between governors and drug traffickers in the region. Reacting to Natividad's candidacy, Doña Lupe runs as opposing candidate with the support of the coyotes.
A runaway bride tries to cross the border to escape from her groom, who is the son of a very influential politician. Natividad wins the elections through fraud and threatens Gama and Morris; they can no longer get anyone else across.
A Russian spacemen's ship lands in Naco by accident. The news spreads fast and the town becomes internationally famous. The Municipal Councellor presents the cosmonauts with the keys to the city while Gama and Morris set out to look for new horizons.
Gama and Morris leave the town along with Wendy. Natividad finds out and sends El Muerto after them. The hitman will do anything in order to fulfill his mission and the coyotes will have to face an unexpected fate.