While ambushing a drug-dealer, Detective Eddie Boone (James Black) is injected in a fight against the dealer with a new drug called Ozone, which transforms the users in powerful zombies. His partner and friend Mike Weitz (Tom Hoover) is kidnapped by a group of Ozone addicted. Eddie tries to find Mike in the streets, fighting against the zombies and having several hallucinations due to the effect drug in his blood.