Rick Jones appears in this game where he meets Bruce Banner for the first time and they become allies. In The Incredible Hulk (2008), Rick Jones is mentioned on the United States Armed Forces' file on Banner, where it states that he met Banner at Culver University before he became Hulk.
Banner arrives in New York City very early in this game and most of the action takes place there. In The Incredible Hulk (2008), the film the game is based on, Banner only reaches New York towards the end, having spent most of the film on the run.
Stark Tower appears in this game. In The Avengers (2012), the tower has only just completed construction. The MetLife Building also appears in the game, despite being the basis for Stark Tower.
The Nelson and Murdock Law Office appears in the game. In Daredevil (2015), Matt Murdock and Foggy Nelson have only just set up their law firm and bought the office at the beginning of the series.
The Baxter Building, the headquarters for the Fantastic Four, also makes an appearance in the game.