While Dr. Massey is still recovering from the loss of his daughter to a maniacal murderer, he embarks on a journey through the unfamiliar world of faith with the guidance of Sister Josepha Montafiore.
With Satanist Isaiah Haden in prison, Dr. Massey tries to return to his old life, then he must investigate the origin of the so-called miracle child, the sole survivor of a shipwreck off Patmos, Greece.
Dr. Massey and Sister Jo travel to Rome to speak with the miracle child's mother, who believes that shadowy figures tried to wrest the baby from her; Massey's stepson (Mark Rendall) is lured away from his bodyguards and into the Satanists' grasp.
Massey's stepson is presented with a horrible choice by his kidnappers; Haden's trial begins, but his charisma and rhetoric gain the respect of his fellow prisoners; the Sisters of Mercy ask for help, fearing their convent has been infiltrated.
In Prague, Massey and Sister Jo find a strange box containing a puzzle that may offer clues about the birth of the Antichrist; Haden's followers attack the Sisters of Mercy Convent and comatose Olivia, while Haden attempts to escape from prison.
The apocalyptic drama reaches its crashing finale. Dr Massey faces a final showdown with his enemy, satanist Isaiah Haden. Can good overcome the ultimate evil?