You know that a film is not meant to be taken seriously when the cast list includes names like Doris Fish, Miss X and Jennifer Blowdryer. This no budget opus, shot in somebody's apartment with a hand held camera, is clearly meant to be a goof. A gay/camp/drag homage to Ed Wood, and to ALL bad grade Z sci-fi films, it was clearly made by people who think they're really clever. They are not.
The film tries so hard to be campy and bad that it succeeds beyond it's wildest dreams. Every single double entendre falls flat, as do all the other jokes, which seemed childish and forced. What makes Ed Wood films so charming now was Wood's total sincerity in his work, and the fact that he had NO IDEA that he was making bad films.
Vegas In Space was made by trendy hipsters who think their inside jokes and deliberately cheap production values are the last word in chic, downtown humor. That they are so impressed with their own fabulousness is painfully obvious and annoying.