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- TC and Topher treat the lone survivor of a plane crash while fending off an intimidating law-enforcement officer with a secret motive. Meanwhile, Paul must deal with an injured exotic dancer whose condition takes a turn for the worse.
- As Drew (Brendan Fehr) struggles to hide an injury, a series of accidents leaves TC (Eoin Christopher Macken) reattaching a hunter's severed hand and lands Jordan (Jill Flint) in the middle of a family feud that threatens to stop a lifesaving blood transfusion.
- San Antonio Memorial's iconoclastic doctors and nurses use their instincts and combat experience to defy the odds and run the chaotic emergency room night shift.
- A dying sheriff's deputy leaves TC (Eoin Christopher Macken) facing giving him a heart transplant for the second time. Landry's (Daniella Alonso) child abuse investigation produces a startling diagnosis.
- Injuries at an Alamo reenactment test the staff. Meanwhile, a disorientated patient suffering from amnesia receives care; Drew helps a severely wounded soldier; Topher schedules a vasectomy operation; and Jordan's boyfriend arrives.
- A series of storms leaves Topher's (Ken Leung) pregnant wife and their daughter stranded on a highway just as she's going into labor. TC (Eoin Christopher Macken) squares off with Jordan's (Jill Flint) boyfriend (guest star Scott Wolf) as he's being courted to head up the hospital's trauma department.
- The aftermath of a serious military bus accident threatens to expose the truth about Drew's (Brendan Fehr) relationship with his boyfriend, Rick. TC (Eoin Christopher Macken) and Scott (Scott Wolf) square off over Jordan (Jill Flint).
- With Topher's (Ken Leung) life hanging in the balance, TC (Eoin Christopher Mackin) is haunted by memories of his brother's death in Afghanistan. Jordan's (Jill Flint) treatment of Dwayne's killer puts her and the hospital on shaky legal ground.
- T.C. is suspended after a breakdown at the hospital; Ragosa returns to the hospital.
- T.C., Kenny and Paul try to save a woman who was accidentally shot by her husband.
- A serious car crash puts a pair of teenage newlyweds and a young pregnant woman in the hospital.
- Joey, T.C. and Gwen try to rescue an injured skydiver after a near-fatal crash.
- Gwen, T.C. and Drew race to the scene of a multi-victim car accident; T.C.'s sister-in-law visits.
- Amid thick fog, the doctors must improvise to save the victims of a car crash.
- T.C. discovers his sister-in-law's complicated history after he treats her for a fall down stairs.
- A downtown gas explosion sends dozens of casualties to San Antonio Memorial Hospital.
- Jordan and Krista provide roadside care for a motorcycle crash victim.
- Drew takes action when a gunman attacks at a friend's promotion ceremony.
- A building collapses during a rodeo; Scott causes a serious car accident.
- When a boy has a serious fever, his high-strung mother starts to exhibit signs of distress.
- Paul sustains injuries during a daring rescue at the scene of a multi-car accident.
- T.C. and Topher return to find Jordan in critical condition and San Antonio terrorized by snipers.
- The overnight crew becomes immeresed in a bizarre car-accident rescue, meanwhile Drew serves overseas in Afghanistan and teams with a colleague to treat an Afghani woman; a spunky grad joins the shift.
- TC and Scott work desperately to save a young boy and his mother who were injured in a car accident. With the boy's life hanging in the balance, the team starts to realize there is more to the family dynamic than meets the eye. Meanwhile, Drew and Syd, deployed overseas in Afghanistan, deal with the aftermath of shots fired in the OR.
- A college co-ed falls from a balcony and once she is in the ER, TC and Paul find that her situation is even more complex. Jordan bonds with a terminal patient who teaches her some important lessons about living. TC's errant sister-in-law Annie returns and hopes to make amends. Meanwhile, Jessica - a pharmaceutical rep with cutting-edge equipment that Scott is so close to getting for the hospital - if her tension with TC doesn't kill the deal.