- Has nystagmus, a condition which causes a person's eyes to move involuntarily.
- Ended up in a drama class by accident in high school due to a computer error in registration.
- When Pruitt Taylor Vince won the 1997 Emmy as Outstanding Guest Actor in a Drama Series for Murder One (1995), he beat Ewan McGregor and such top-drawer thespians as Oscar-winners Alan Arkin and Louis Gossett Jr. and Oscar nominee William H. Macy for the award.
- Won the 1997 Emmy Award for Outstanding Guest Performance by an Actor for his performance as serial killer Clifford Banks on Murder One (1995).
- Nominated for Best Supporting Actor at the Northeast Film Festival 2013 for his stellar performance as Earl Wayne in Broken Blood (2013).
- Filmed scenes for Down by Law (1986) that were cut.
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