- Her husband Stanley died in 1935, but until her death, she often had "conversations" with her late husband, occasionally interrupting a scene in a movie. She would then let the director know it was okay to continue the scene, which she did as if nothing happened. James Whitmore, her co-star in Mrs. O'Malley and Mr. Malone (1950), talked about this in a TCM tribute to Main.
- Starred in "Ma and Pa Kettle" movies as Ma Kettle. She made a total of eight movies with Percy Kilbride as Pa Kettle.
- Had been known to wear white gloves and a surgical mask for fear of germ contamination.
- In her autobiography Unsinkable, Debbie Reynolds states that Main would bring the urn containing her late husband Stanley Krebs' ashes with her to the MGM commissary, order an extra meal for Stanley and carry on conversation as if he were still alive and well and joining her for the meal.
- Her husband, Stanley Lefevre Krebs, was born February 14, 1864 in Waynesboro, Pennsylvania.
- She was never under contract to Universal-International when she appeared in the "Ma and Pa Kettle" movie series. She was on loan to Universal by Metro-Goldwyn-Mayer.
- Profiled in book "Funny Ladies" by Stephen Silverman. (1999)
- Though her last official professional credit was on two 1958 episodes of Wagon Train (1957), she was one of the guests at the premiere of That's Entertainment! (1974), appearing on stage with many of her great colleagues at the gala post-premiere party.
- She attended Franklin College in Franklin, Indiana.
- Biography in "Actresses of a Certain Character: Forty Familiar Hollywood Faces from the Thirties to the Fifties" by Axel Nissen.
- Her father, Rev. Samuel J. Tomlinson, was the pastor of the Christian Church in Elkhart, Indiana.
- Appeared three times with Judy Garland: "Meet me in St. Louis" (1944), :The Harvey girls" (!946), and Garland's last film for MGM, "Summer stock" (1950).
- As a result of their successful collaboration in The Egg and I (1947), she and Percy Kilbride were reunited in Feudin', Fussin' and A-Fightin' (1948), their first and only non-Ma and Pa Kettle movie.
- Main's career was highlighted in "The Slapstick Queens" by James Robert Parish, published by A. S. Barnes in 1973.
- Longtime companion of actress Spring Byington.
- Appeared in seven films with Wallace Beery: Wyoming (1940), Barnacle Bill (1941), The Bugle Sounds (1942), Jackass Mail (1942), Rationing (1944), Bad Bascomb (1946) and Big Jack (1949).
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