- A prominent actor shadows Larry to prepare for an upcoming role; Larry meddles in the sale of Cheryl's sister's house, helps Leon grow a new business, and stirs up trouble at a dinner party hosted by Richard's girlfriend.
- Jeff tells Larry that actor Jon Hamm is playing a Larry-type character in a movie. Hamm wants to learn the role, so he shadows Larry for a day. On this said day, Larry helps a newspaper vendor by covering for him while he goes to the bathroom. He later tells Larry that this was worth $10 to him. Larry talks to Leon about this business opportunity, of covering for attendants while they go to the bathroom.
Leon and Larry go into business providing short term relief for workers who need to use the bathroom during their shifts.
Cheryl tells Larry that her estranged sister Becky (Kaitlin Olson) is selling the house that Larry gave her as a gift. Angry that Becky will turn a profit, Larry confronts her, asking for the money back. The two end up having sex and begin a relationship, much to Cheryl's chagrin. When Cheryl is yelling at Larry, Hamm is sitting right there witnessing the whole thing.
Susie and Jeff are fighting, and she throws Jeff out of the house for defending Larry for having sex with Becky. Jeff goes to live with Larry.
Larry helps Becky clean up her entire house (it was a sodding mess) and that results in a quick sale, post which Becky leaves for a Ski vacation. After breaking her leg in a skiing accident, Becky is disappointed by Larry's failure to hurry to Denver to see her.
Larry didn't go immediately as the flights only had coach seats left and the first flight to Denver with First class seat was at 9pm. But Larry can't catch that flight as Leon has an emergency and needs Larry's help to cover for a newsstand vendor while he has to go. When the newsstand vendor won't come back for 15 mins, Larry asks Jon Hamm for the favor. Larry gets to the airport but misses his flight when he is selected for a random security check.
Larry takes the 2nd flight out the next day, as the first flight didn't have first class tickets. He lies to Becky that he waited for a first-class seat because he has a bleeding rectum. Becky breaks up with him as she sees through the BS.
Meanwhile Cheryl shows up at the newsstand and starts chatting up with Jon Hamm. Jon leaves the newsstand unattended to go have coffee with Cheryl. Hamm becomes too similar to Larry. They go to Mocha Joe's and Jon complains about the scone, the wobbly table and the cold coffee, just like Larry did, and Cheryl storms out on him during a coffee date. Meanwhile the newsstand is completely robbed and destroyed and the attendant returns and is enraged at Larry.
Larry and Hamm get thrown out of a dinner party hosted by Richard Lewis, his girlfriend (Sasha Alexander). That is because Richard told his girlfriend that Larry has a bleeding rectum, but never told her that he recovered weeks ago. so now, the girlfriend is paranoid, whenever Larry wants to sit down anywhere. She gets Larry a wooden chair to sit, but Larry fights with Richard to get a regular cushy chair at dinner. But at the dinner table Larry enrages Andy's wife by making sexist comments, who throws a bowl of ketchup at him, which stains the chair none-the-less, and Larry's Cousin Andy (Richard Kind).
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