Initially, a UFC Light Heavyweight Championship bout between champion Daniel Cormier and top contender Alexander Gustafsson was linked as a possible event headliner. Although never officially announced by the UFC, the bout between Cormier and Gustafsson would not take place at this event and would instead be postponed and moved to UFC 192.
During the live Fox Sports 1 broadcast of UFC Fight Night: Mir vs. Duffee, it was confirmed that a UFC Flyweight Championship bout between champion Demetrious Johnson and top contender John Dodson would headline the event. Their first fight at UFC on Fox: Johnson vs. Dodson ended in a unanimous decision victory for Johnson.
Anthony Johnson, Raquel Pennington, John Lineker and Francisco Rivera earned $50,000 UFC 191 fight-night bonuses.
UFC 191 drew an announced attendance of 10,873 for a live gate of $1,362,600.
Betting favorites went 6-5 on the card.