- Oscar Rankin: I can't believe it's been three years.
- Sherlock Holmes: Yes, well... time flies when you're on heroin.
- Sherlock Holmes: You're positive I didn't do it.
- Joan Watson: Of course, I am.
- Sherlock Holmes: How?
- Joan Watson: Because I know you.
- Sherlock Holmes: Yes. Better than anyone. But, let me make one thing perfectly clear. You did not know *him*. You never met *him*.
- Joan Watson: So, you're Dr. Jekyll now, and he's Mr. Hyde?
- Sherlock Holmes: You continue to misunderstand. At that point in my life, I did not plumb down into some dark part of myself. I *detached* from myself. From all that was essential to me. To say that you can guess what I was capable of is illogical! I was a different person. And the fact that I remember so little from that time has been *nothing* but a *tremendous* relief to me! Until now!
- Sherlock Holmes: [to Watson] It's a form of torture... Having to swim through my old life. I know that over the years, you've suffered your own travails, and you can relate to a profound sense of guilt. You cannot relate to a profound sense of shame.
- Joan Watson: Where are you going?
- Sherlock Holmes: Walk.
- Joan Watson: It should trouble me, right? How often I believe that.