On Halloween, the Agents of S.M.A.S.H. encounter Nick Fury's Howling Commandos where they have been sent by Nick Fury to apprehend the Agents of S.M.A.S.H. The Howling Commandos have a change of plans when they end up helping the Agents of S.M.A.S.H. prevent Dormammu from breaking into Earth's dimension and turning all of humanity into Mindless Ones.