- Dr. Frederick Chilton: The optimist believes we live in the best of all possible worlds. The pessimist fears is this is true. This is your best possible world, Will. You're not getting a better one.
- Jack Crawford: You remember when you decided to call Hannibal?
- Will Graham: I wasn't decided when I called him. I just called him. I deliberated while the phone rang. I decided when I heard his voice.
- Jack Crawford: You told him we knew.
- Will Graham: I told him to leave, 'cause I wanted him to run.
- Jack Crawford: Why?
- Will Graham: Because... Because he was my friend. And because I wanted to run away with him.
- Dr. Alana Bloom: Friendship with Hannibal is a blackmail elevated to the level of love
- Will Graham: Mutually unspoken pact to ignore the worst in one another in order to continue enjoying the best
- Dr. Alana Bloom: I've always enjoyed the word 'defenestration.' Now I get to use it in casual conversation.
- Dr. Frederick Chilton: How many bones did you break?
- Dr. Alana Bloom: You say that like I broke them.
- Dr. Frederick Chilton: It's only a matter of time before they are back in each others arms. Shame not to have the good seats.
- Dr. Frederick Chilton: I do not mean to kick you when you are down. I'm just reminding you of how you got down.
- Dr. Alana Bloom: Forgiveness isn't all it's cracked up to be, Mr. Verger. I don't need religion to appreciate the idea of Old Testament revenge.
- Mason Verger: I would like you to begin arrangements for Dr. Hannibal Lecter to be eaten alive
- Dr. Cordell Doemling: Do you have a preference for how you would like him prepared?
- Mason Verger: Oh, Cordell - if I had lips I would smile.
- Dr. Alana Bloom: I'm not sure if this is my entrance.
- Margot Verger: This can be your entrance. It isn't easy to find the first time you come.