This episode features a reunion of Scream 3 co-stars Patrick Dempsey and Neve Campbell.
Every episode of the show is named after a song. "Run, Baby, Run" is either in reference to a song by Sheryl Crow, or by alt-rock band Garbage.
Neve Campbell starred on the show as Lizzie Shepherd, the sister of Dr. Derek Shepherd. Patrick Dempsey who plays Dr. Derek Shepherd played together with Neve Campbell in Scream 3.
This takes place in December 2012.