Antonio Albanese plays the three main characters Rodolfo Favretto, Frengo Stoppato and Cetto La Qualunque. The latter two ones are recurring characters of Albanese's performances. Frengo Stoppato (before this movie known only as Frengo) was originally a hooligan of his hometown's football club Calcio Foggia and a fan of coach Zdenek Zeman. Introduced in the TV show Mai dire gol (1990) on channel Italia 1, he was particularly known for his surreal commentaries of his club's games. In the movie his character focuses less on his football interest and more on his cannabis addiction, which led him to move to South America. Cetto La Qualunque is a corrupt and sexist politician from Calabria, first introduced by Albanese in 2003 in the TV show Non c'è problema on state-owned TV RAI and then often proposed again on other shows for RAI and Mediaset channels. After the great success of his performances as Cetto in the TV show Che tempo che fa (2003) starting from 2007, Albanese decided to make a movie about the character, Qualunquemente (2011), followed by Cetto c'è senzadubbiamente (2019). The appearance of Cetto in this movie describes his adventure in Rome with national politics, after having become mayor of his village in the first movie and before moving to Germany in the second movie. The character of Rodolfo Favretto, a racist politician from Northern Italy, was purposely created for this movie. As of 2020 his appearance in this movie is his only appearance.
Most characters around Cetto La Qualunque ( Antonio Albanese ) are the same of his first feature movie Qualunquemente (2011) and of its sequel Cetto c'è senzadubbiamente (2019): his wife Carmen ( Lorenza Indovina ), his son Melo ( Davide Giordano ), his friend Pino ( Nicola Rignanese ) and the engineer ( Massimo Cagnina ). Also Carmine ( Luigi Maria Burruano ) appears in this movie, but not in the 2019 sequel due to actor Luigi Maria Burruano's death. Missing characters from the first Cetto movie are his trainer Gerry Salerno ( Sergio Rubini ), his South American lover Cosa ( Veronica Da Silva ), his rival Giuseppe De Santis ( Salvatore Cantalupo ) and his fake disabled friend ( Mario Cordova ).
This movie forms together with Qualunquemente (2011) and Cetto c'è senzadubbiamente (2019) the so called "Pilu-trilogy", from Cetto La Qualunque's usual dialectal term to refer to women.
In his first feature movie Qualunquemente (2011) Cetto La Qualunque used to drive a Hummer H2. In this movie he travels with a same model with stretched body.