The Superman costume featured in this episode was previously worn by Brandon Routh in Superman Returns (2006).
Mackenzie Gray, who plays Lex Luthor's clone, also played Dr. Alistair Kreig in S5 E15 Cyborg, and would later play Jax-Ur in Man of Steel (2013).
Ted Whittall, who plays Rick Flag, also played Carter Bowfry, the man who trained Lana, in S8 E13 Power. He later played Kristin Kreuk's father in Beauty and the Beast (2012).
Tom Welling (Clark) and Allison Mack (Chloe) are the only cast members to appear in every season premiere.
Interestingly in the beginning after Lois saves Clark, she hides to see Clark use his powers. This is quite literally the same thing Lana does to Clark in Season 6 Episode 16 "Promise".