the scene when Kyle is forced to drink three cups of urine in order to prevent his body to not endure the effects of fluid pressure before swimming down to drain it all out, is a parody of a scene in the Abyss, where the protagonist consumes a liquid breathing apparatus before venturing into the ocean depths
They claim that the urine causes high amounts of aggression like the disease Rage, also when they urinated on the monkeys it refered to the infected chimps from the opening scene of the film.