Ron Chaney (Bela Reinhardt) is the grandson of Lon Chaney Jr., who played Lawrence Talbot / The Wolf Man in The Wolf Man (1941), Frankenstein Meets the Wolf Man (1943), House of Frankenstein (1944), House of Dracula (1945) and Abbott and Costello Meet Frankenstein (1948).
The title is clearly a nod to the, "The house of" franchise/original Frankenstein series. I.E. The house of Frankenstein, house of Dracula, and etc.
Michael R. Thomas's last film; it's dedicated to his memory via end credits.