Two separate locations had to be used for the final battle in the woods at the end because it was illegal to use fire within Houston City limits.
The character name Alana is a tribute to Alanis Morissette, who is the favorite singer of the actress Rebecca Torrellas who plays Alana.
Stephen Payne (who plays the comic book reader), came up with the idea that there are 3 lines that should NEVER be said in a film because they are the most overused lines in film history: "We don't have time for this," "Everything you ever told me was a lie," and "Let's do this!" The director decided there should be a character who says all 3 of those lines, adding "That's what she said" just before being killed by zombies.
There are 2 other actors who double for the serial killer in small parts of the film.
Some scenes were filmed and then corrective shots were added months (or even a year) later to fix up a scene.