The character of Lucy was originally written to be the middle sister, but Josie Hull's audition, for which she edited an entire vlog in character, full of TikTok-style jump-cuts, and featuring her heavily improvised sassy humor, was so strong that she was rewritten to be the youngest.
Gabe Rodriguez conducted several improv-sessions with the four lead actresses via Zoom to create the sister-dynamic and banter. Many lines of dialog from these improv-sessions ended up in the final script. The first time the four leads actually met in person was on the first day of filming.
Despite being filmed during the height of a pandemic, not a single cast or crew member ever contracted Covid the entire shoot.
Gia Galardi originally auditioned for Lucy, but her performance was so jaded and embittered that the role of Carolyn almost immediately wrote itself.
Kimberly DiPersia, who plays Aymara the poet, and Chelsea LeSage, who plays Lady Macbeth in the Shakespeare In the Park sequence, were in fact roommates at the time and both members of the sketch comedy series The Egos (2016). The production had no idea of this and cast each one independently, their scenes filmed months apart.