CBS announced in Feb. 2021 that it gave a straight-to-series order to CSI: Vegas, a sequel to the mothership CSI series, CSI: Crime Scene Investigation (2000), for the 2021-22 season and that it will be led by returning CSI stars William Petersen and Jorja Fox as Gil Grissom and Sara Sidle. After the ending of the first season, Petersen and Fox did quit from the series. For the second season it was announced the return of Marg Helgenberger as Catherine Willows.
Paul Guilfoyle, who played Captain Jim Brass on the original series, reprised his role in this revival series, as TVLine confirmed in May 3, 2021.
The first episode was shot on May 5th 2021 according to an Instagram post by one of the actresses.
Matt Lauria, who plays Josh Folsom, is not a newcomer to the CSI franchise. He played Agent Matthew Pratt in Zippered (2011), Ms. Willows Regrets (2012) and Willows in the Wind (2012).
Robert Curtis Brown, who plays Undersheriff Cade Wyatt, is not a newcomer in the CSI franchise: he played Marc Snowden in Innocent (2004), Dan Keaton in Swap Meet (2004) and Davis Ollenstein in Redemption (2010).