Showrunner Carina Adly MacKenzie stated that the episode is "all about Michael Guerin" and that actor Michael Vlamis made her cry during rehearsal
The song playing when Isobel enters Max's mind as he's dying is "First Day of My Life" by Bright Eyes, the song that he and Liz were listening to in the flashback to their trip out to the desert right before Rosa died (in episode 1x6, "Smells Like Teen Spirit").
The episode is named after the song "I'll Stand By You" by the Pretenders, released in 1994.
This is the first television episode written by Alanna Bennett.