- In the Japanese version of the game, in the quest "The Power of the Atom" Mr. Burke has been removed leaving no possibility of destroying the town of Megaton. This was done because the developers feared the Japanese government would not allow the game to be distributed in Japan if it featured the possibility of detonating an atomic bomb in a populated area.
- In the Japanese version of the game, the "Fat Man" mini-nuke launcher was renamed the "Nuks-Launcher". This was done because the bomb the United States dropped on the Japanese city of Hiroshima was nicknamed Fat Man.
- To avoid being indexed by the BPjM, the German version was modified to completely remove the blood and gore from the game.
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