The story follows Elmerulia Frixell, known to her friends as Lulua, who is the daughter of the famous alchemist Rorona and the apprentice of the alchemist Piana. Lulua's biggest dream is to surpass her mother in the craft. They live in Arklys, a town located in one of the frontiers of the Arland Republic. One day, Lulua comes across a book that only she can read, the Alchemyriddle, and discovers that she has a certain power. She then decides that she has to decipher all of the book; a decision that will lead her to discover the truth about the whole of Arland.