When ghosts invade Janine's apartment during a large outbreak of paranormal activity, the Ghostbusters are to loaded down by other activity transpiring on a large scale around the city. Since the Ghostbusters are unable to help, Janine has to try and bust the ghosts herself. Slimer comes along with her and while he's useless at first, he helps Janine capture the ghosts. When they return to the firehouse, they see on television that a ghost the guys have been fighting has captured them. So, Janine and Slimer head out to clean up some ectoplasm.