- Mr. Garrison: [to Mr. Slave as he decides to walk out after Mr. Garrison got a sex change operation] Go ahead and find someone who doesn't have a vagina you fag.
- Mrs. Garrison: You mean I'll never know what it feels like to have a baby growing inside me and then scramble its brains and vacuum it out?
- Mrs. Garrison: Hello boys! It's me - your teacher, Mrs. Garrison!
- Cartman: [to Stan, Kyle and Kenny] You guys - Mr. Garrison has titties.
- Mrs. Garrison: I had a sex-change operation. My penis is now a vagina, and I'm experiencing womanhood for the first time in my life!
- [walking away]
- Mrs. Garrison: See you in class!
- Butters Stotch: Fellows! Hey, Fellows! You gotta come see!
- Stan Marsh: What?
- Butters Stotch: It's Kyle! He's a negro!