When Lisa is singing in front of the mirror, the song is to the tune of "La donna è mobile" from Verdi's "Rigoletto".
Homer's "Game over man, game over" is a reference to Bill Paxton's character in Aliens
The B-plot features Lisa taking Italian lessons from Milhouse to prepare for a trip to Italy. In the next episode, "The Italian Bob", the Simpsons travel to Italy.
Per the title, the original Broadway production of "Last of the Red Hot Lovers" by Neil Simon opened at the Eugene O'Neill Theater on December 28, 1969, ran for 706 performances and was nominated for the 1970 Tony Award for the Best Play.