The house used to the exterior shots is the same one used as the title characters' residence in The Munsters (1964).
The episode's villain, Jake Dorleac, is named after the series' principal costume designer Jean-Pierre Dorléac.
The title is based upon the drink Southern Comfort, a fruit, spice, and whiskey flavored liqueur produced since 1874.
The doorbell of the house is the Dixie tune similar to the horn on the General Lee from The Dukes of Hazzard (1979).