The college that Karen is seen walking on campus is University of North Carolina - Wilmington. Wilmington, NC is where OTH was filmed
Brooke: You guys totally have the whole Nick and Jessica thing going on, just without the stalkerazzi and chickeny-tuna.
An obvious reference to Jessica Simpson and Nick Lachey, who got married and made a reality TV show out of their married life. One of the highest points of the TV show was Jessica confusing chicken with tuna.