Arte Johnson (J.J. Wilson) is the only actor to appear in "The Flip-Side of Satan." This is the only time in the entire run of the series that only one actor appeared in a segment.
The segment "The Flip-Side of Satan" employs an optical effect which uses some of the same footage (a man's face shot in close wide angle) that is used briefly in the Night Gallery opening title sequence.
Jack Laird, who played the laboratory assistant in the segment "With Apologies to Mr. Hyde", was one of the series' producers.
After La Strega (1962) and Jess-Belle (1963), this was the third time that Jeanette Nolan played a witch.
James Farentino (Craig Lowell) and Michele Lee (Joanna Lowell) were married in real life at the time that "Since Aunt Ada Came to Stay" was filmed.