When Brian has the flashback about hanging out with Andy Warhol in the 1970s, at one point he is doused with a large can of Campbell's soup. This is a reference to one of Warhol's most famous works of art, which depicted a hundred Campbell's soup cans.
One scene shows Brian in the fictitious movie "Andy Warhol's 'Lassie'". Later, Antonio Monatti mentions "Interview" magazine, another Andy Warhol creation.
Murphy Brown (voiced by Candice Bergen) is wearing the same earrings that the character Gloria Ironbox (also voiced by Candice Bergen) was wearing in the episode "I Am Peter, Hear Me Roar."
The title is based on the old Chinese proverb, "A picture is worth a thousand words."
When Antonio Monatti changes Chris' name to Christobel, this is possibly a reference to real-life conceptual artist Christo.