Yes, both have the same premise...the Kingpin has framed Spider-Man, making it seem he has planted a bomb in New York. Of course, he is only doing this to turn New York against Spidey so they will go after him and hopefully take care of the webslinger once and for all. In the genesis version you go through a basic progression of levels side scrolling style. Pretty straight forward, go through a level and fight a boss at the end. You have Doc Ock, Electro, the Lizard, Venom, the Sandman, Hobgoblin and the Kingpin. Each one other than Kingpin has a key that goes to the nuclear bomb and the last stage you have a big battle royal with this villains before you face off against the Kingpin. You also have a cool picture taking feature that rewards you for cool shots you take. This is sadly left out of the sega cd version which has a bit more added depth with animated cut scenes and two additional villains: The Vulture and Mysterio. The levels are also done on a map in which you have to find the villains a bit, but once you select a level it is basically the side scroller the genesis version is. The games are both rather simple, the cd version being a bit easier, however, playing them now you will notice they are both short. I won the cd version in an hour worth of time. The music is better in the genesis mode as the cd uses a horrible soundtrack. I also wish the cd version had kept the picture taking as it replaces it with a stupid collect comic books feature and if you get them all you get absolutely nothing!