Holmes and Moriarty appear to be vaporized when both fall into a Laserwave sanitation grid. Watson and Lestrade investigate a case of foul play at the Holocade Tournament.
Inspector Beth Lestrade of New Scotland Yard is convinced that Professor Moriarty has returned from the dead, so she asks biologist Sir Evan Hargreaves to cellular rejuvenate Sherlock Holmes, who's body has been preserved in honey for nearly 200 years.
A man who prefers to live without the use of modern technology is poisoned and sends his young son to fetch Sherlock Holmes. Watson, however, being mechanical, is not welcome.
Lestrade is infected by mind-altering nanobots and goes on a rampage. The only clue is a Chinese puzzle box. When another one turns up at Holme's doorstep, he begins to show the same symptoms.
Fenton steals the Musgrave sword from the British Museum. Moriarty thinks he has deciphered the Musgrave ritual that leads to a powerful meteor from which the sword was forged.
A computer vampire is crashing New London's largest computer grids and sucking their data dry. Lestrade asks Holmes and the Irregulars to help uncover the vampire's identity, while Moriarty wants it as his new partner in crime.
Blue Carbuncles are the number one sold out Christmas toy. But one Carbuncle turns out to be more sophisticated and life-like when activated. This particularly toy is on Holmes, Moriarty and it's inventor's wish list.
20 years after her father died during a moon-quake, Mary Morstan is summoned to the moon by the son of her father's business partner. Holmes and Watson are invited along for the ride.
Martin Fenwick is turning innocent citizens of New London into criminals and sends them out to commit a crime wave. Holmes and Lestrade meet the new Baker Street Irregulars: Wiggins, Deidre and Tennyson.