This cartoon was a huge success when it first aired on ABC and later became one of the first cartoons to air on the Fox channel's Fox Kids lineup. This led to Beetlejuice being seen Monday through Friday on FOX while still remaining on ABC's Saturday morning schedule, making it one of the few shows in American TV history to be aired concurrently on two different broadcast networks.
It is not known who played the announcer who says "Now here's Beetlejuice" during the title card and "Now back to Beetlejuice" after the commercial break; the actor is not credited in the end credits, and to this day the actor's identity remains a mystery.
The reoccurring character Prince Vince is the same one used for the title character Vincent (1982), an early Tim Burton short.
Kenner, the company behind the Beetlejuice movie action figures, had begun developing figures for the animated series, but the project did not come to fruition. One prototype figurehead of Jacques LaLean for that ill-fated collection has been showcased online.
Jacques LaLean the bodybuilding skeleton and Ginger the tap-dancing spider are based on fitness guru Jack LaLanne and dancer/actress Ginger Rogers.