Although the film is often referred to as "Andy Warhol's Frankenstein," he wasn't directly involved in the production, but allowed the director to use his name. Warhol would make rare visits to the sets and during the editing period.
The gory special effects are an early example of the work of Carlo Rambaldi who would later go on to do the special effects for E.T. the Extra-Terrestrial (1982).
According to Luigi Cozzi, Antonio Margheriti allowed his friend producer to use his name as the official Italian director of this film in order to keep financial help from the state. However, this stunt led to a costly prosecution for both Margheriti and the producer.
The film was rated X in the USA due to its explicit depiction of sex and violence.
Originally filmed in 3D, although most presentations found today are in 2D.