In 1960 he debuted Barry Farber's Open Mike on WINS/New York. Two years later he began a 15-year association with WOR/New York as an evening and overnight host, leaving in 1977 to run for mayor, but he returned to radio the following year for a decade-long run at WMCA/New York. In 1990 Farber's show went national as part of the ABC Radio network, and he later tried his hand at syndication behind the scenes as a co-founder of the independent network Daynet. Since 2008 The Barry Farber Show has been heard on CRN Digital Talk Radio and Talk Radio Network.