- Defender for Vélez Sarsfield (Buenos Aires, 2008-2010), F.C. Porto (Portugal, 2010-2013), Atlético Mineiro (Brazil, 2014), Valencia C.F. (Spain, 2014-15), Manchester City F.C. (England, 2015-2020) and S.L. Benfica (Portugal, 2020-).
- Honours with Vélez Sarsfield: Argentine Primera División (2009 Clausura). Honours with F.C. Porto: Primeira Liga (2011, 2012, 2013); Portuguese Cup (2011); Portuguese Super Cup (2011, 2012, 2013); UEFA Europa League (2011). Honours with Manchester City F.C.: Premier League (2018); EFL Cup (2016, 2018, 2019); FA Community Shield (2018).
- International with Argentina National Football Team since 2009. Member of the Copa América 2015, 2016, 2019, 2021, and the South Africa '10 and the Russia '18 squads.
- Named in the South American Team of the Year in 2009.
- Father of, with Celeste Rey, Mía (b. 2009) and Valentín (b. 2014).
- Named in the La Liga Team of the Season in 2015.
- Member of the Argentina National team who finished runners-up of two Copa América (2015 and 2016).
- Named in the Copa América Team of the Tournament in 2015 and 2016.
- Named in the 2017-18 Premier League PFA Team of the Year.
- Member of the Argentina National team who won the 2022 FIFA World Cup, the 2021 Copa América at Maracanã Stadium (their first title since 1993) and the 2022 CONMEBOL-UEFA Cup of Champions at Wembley Stadium.
- Has a daughter called Morena (b. 2007).
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