- 7th round pick by the New England Patriots in the 2005 NFL draft out of USC. Was the back-up to Carson Palmer and Matt Leinart.
- His wife is a member of USC's 2002 NCAA Champion women's volleyball team.
- Son of Gregory Cassel and Barbara Cassel.
- Was traded by the New England Patriots to the Kansas City Chiefs on February 28, 2009.
- (8 September) Named the Patriots' starting QB after Tom Brady suffered a season-ending knee injury the day before against Kansas City. Cassel has not been a starter since high school. (2008)
- Was placed under the franchise tag of the Patriots. He is set to earn $14.6 million in 2009 if he is not traded before the 2009 season. (February 2009)
- Traded to the Kansas City Chiefs along with fellow Patriot Mike Vrabel for a second-round draft pick for New England. (February 2009)
- Released by the Buffalo Bills. [September 5, 2015].
- Signed to the Buffalo Bills practice squad. [September 8, 2015].
- Traded to the Dallas Cowboys. [September 22, 2015].
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