- He was born in a tin-roofed shack in a working-class neighborhood of Montevideo. As a young man, he sold newspapers and installed windows.
- He earned high marks in medical school and chose to specialize in oncology after a sister, brother, and his father died of cancer. He opened a clinic in an impoverished neighborhood. He stayed active in his medical practice after becoming a public official, continuing to work one day a week even during his first term as president of Uruguay.
- He was elected mayor of Montevideo, Uruguay in 1989. He became president of Uruguay starting in 2005.
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