- In 2012, Luna was diagnosed with cervical cancer after giving birth to her youngest child Nina. Two years later, the cancer returned, and she received her last chemotherapy treatment in 2015. By 2016, the cancer had returned, and affected the left side of her neck. Unfortunately, just three days after her 38th birthday, Karla Luna passed away. She spoke on TV and implored authorities not to separate her children after she died.
- Had four children with her ex-husband Americo Garza. Had at least three daughters including Sara Valentina (b. 2009) and Nina Victoria (b. 2012).
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