- Marisa's big break came at age 21 when well-known fashion photographer Mario Testino photographed her while she was surfing with friends in Manhattan Beach, Calif.
- Gave birth to her 1st child at age 34, a son named Gavin Lee Guess on December 13, 2012. Child's father is her 2nd husband, Griffin Guess.
- In May 2004, she finished second in the celebrity division of the 'Kelly Slater' Invitational in Fiji.
- Gave birth to her 2nd child at age 36, a son named Grayson Lee Bazyl Guess on May 29, 2015 in Santa Cruz, California at 11:23 p.m. weighed 8 lbs., 14 oz., and measured 21 inches long. Child's father is her 2nd husband, Griffin Guess.
- In high school, Marisa was a star volleyball player. In her junior year, thanks to her position as outside hitter, her team never lost a game during the entire season.
- Fan of the San Francisco Giants.
- Has appeared in seven editions of the Sports Illustrated swimsuit issue (2002-2008).
- Was voted the global winner of FHM Magazine's Sexiest Women in the World internet poll in 2010.
- Ranked #7 in the 2011 FHM list of "100 Sexiest Women in the World".
- Along with Nicole Richie, Beyoncé, Veronica Webb, Kelly Osbourne, Angie Everhart, Alexandra Richards, Irina Pantaeva, Wyclef Jean, Rachel Hunter, Naomi Campbell, and Janice Dickinson, she participated in the "Fashion for Relief" show on 16 September, 2005 in New York, a benefit for AmeriCares to support victims for Hurricane Katrina. Gwen Stefani and Gavin Rossdale were among the celebrities who attended.
- Ranked #2 in the 2010 Ask Men list of the top 99 "most desirable women".
- Ranked #3 in the 2009 Ask Men list of the top 99 "most desirable women".
- Ranked #17 Sexiest Woman in the world by the Spanish version of DT magazine.
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