- Born into a fourth generation deaf family, Shoshannah's first language is American Sign Language. She also reads lips and comfortably speaks without an interpreter.
- Born into an observant Jewish and fourth-generation deaf family. One of her grandmothers is a Holocaust survivor.
- Attended Gallaudet University, the only liberal arts college for the Deaf in the world.
- Her name means "lily" in Hebrew.
- Gave birth to daughter Mayim Helene Mitchell on February 18, 2015.
- Her role on ABC's Threat Matrix (2003) was written for her after the director and producers saw her work on an episode of The Division (2001).
- Married Ricky Mitchell in Santa Fe, New Mexico.
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