- Studied marine biology at Orange Coast College, where he met his wife, Cathi.
- Chosen for the title role on The Tick (2001), the short-lived, live-action series due to his size. The producers were astonished by the size of the "crater" he left in the couch when he came in to discuss the role.
- Plays "Patrick...your flight attendant" on Soarin' at Walt Disney World' EPCOT and Soarin' Over California at Disney's California Adventure (2005)
- Although he is well known for his height and hugely broad frame, he has said that he was rather short and slender in his teenage years.
- Dropped the puck to start the game after the New Jersey Devils raised their 1995 Stanley Cup banner as the "face Painter" character from Seinfeld (1989).
- Has done the voice of an animated Superman twice: Once during an episode of Family Guy (1999) and again for Jerry Seinfeld's Seinfeld/Superman series of American Express commercials.
- His father, Dr. John (Jack) Charles Warburton III (1935-2017), was an orthopedic surgeon.
- Warburton appeared on the auto enthusiast show Top Gear (2002) and revealed to host Adam Ferrara that he owns/owned a previously wrecked Dodge Viper and a coveted '69 Dodge Charger R/T. He refers to them as Pamela and Angelina respectively.
- He got a VFD tattoo on his left ankle after his role as Lemony Snicket on "Lemony Snicket: A Series Of Unfortunate Events".
- Is the namesake of the "Patrick Warburton Manliest Man Award" given by the Dallas, TX radio show "Pugs and Kelly" on 105.3 FM.
- Appeared in Big Trouble (2002) with Tim Allen. Both have voiced Buzz Lightyear.
- Suffered through what may be the longest flogging in screen history in Dragonard (1988). He plays a slave on a 17th-century Caribbean island who's sentenced to 100 lashes across his back for insubordination to his master. The lashes are delivered in the public square, are counted out by enthusiastic spectators, and from start to finish consume about 3 minutes and 50 seconds of screen time.
- Was a model for Bugle Boy Clothes.
- Father of Talon Patrick (b. 1992), Alexandra Catherine (b. 1994), Shane (b. 1998) and Gabriel (b. October 2000).
- The Woman Chaser (1999) was the first feature film in which he played the lead character. He portrayed the role of an eccentric used- car salesman who became a wannabe movie director. The film was nominated for the 2000 Sundance Film Festival.
- Attended Servite High School in Anaheim, California where he ran on the cross country team with Michael McDonald. He later transferred to Newport Harbor High School in Newport Beach, California, where he graduated in 1982.
- His father was of Irish, English, Alsatian German, Slovenian, and French descent. His mother is of German ancestry.
- Along with Richard Kind, starring in radio commercials portraying "Lewis & Clark", for Horizon Air (a smaller branch of Alaska Airlines), in the Seattle Area. (2006)
- He is currently living in Ventura County, California. (2004)
- Son of Barbara Lord.
- Scene in A Mighty Wind (2003) was cut and is in the deleted scenes on the DVD.
- Older brother of Tom Warburton.
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