- In July 2017, he was revealed by the BBC to be the corporation's highest paid actor.
- The only original cast member of Casualty (1986) to never have left the series.
- He has played the same character (Charlie Fairhead) on three different series: Casualty (1986), Holby City (1999) and Holby Blue (2007).
- He has a twin sister, Elaine Thompson. In the early sixties they formed a singing duo, Elaine and Derek, and had a few records released. They appeared together in the film, Gonks Go Beat (1964).
- Derek Thompson met his wife, Dee Sadler, when she appeared as Maggie, a cave explorer, in an episode of Casualty (1986) in which Derek plays Charlie Fairhead. Charlie rescued Maggie when she was trapped underground after suffering a fit.
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