Santiago is a close friend of director Guillermo del Toro. He appears in most of del Toro's American films in cameo bit parts and is a frequent collaborator on many of del Toro's projects.
He used to take part in TV shows and contests in order to earn money for making his first short films.
Well-known for appearing as a guest in almost every successful TV show
in Spain to promote his "Torrente" films.
Has two daughters with María Amaro. The first child, named Calma, was born on February 7, 2008. The second one, named Sirena, was born on December, 2013.