- Has appeared in 3 movies with his best friend Gaspard Ulliel: Brotherhood of the Wolf (2001), A Heavenly Vintage (2009) and Saint Laurent (2014).
- Both his parents are Osteopaths.
- Brother Yannick Renier is also an actor.
- Speaks French and English and has starred in Belgian, French, New Zealand, Argentinian and British films. He also learned Spanish for the film White Elephant (2012).
- Former companion of actress Natacha Régnier (1998-2000), his co-star in Criminal Lovers (1999) and Le pont des Arts (2004).
- Moved to France at 17 and lives alternately in Paris, Valence, and Brussels, Belgium.
- Former companion of Helene Helinck, a one time TV presenter, now a kids fashion designer, with whom he had two sons.
- Has three children. Sons Arthur and Oscar (born in 2001 and 2006, respectively) from his relationship with Helene Helinck, and a daughter, Camille (born in 2018), from his relationship with Laura Léonard.
- As of 2022, Renier has starred in 14 films that have premiered at the Cannes Film Festival, 7 of them have competed for the Palme d'Or in the main competition section: The Child (2005) (winner), Lorna's Silence (2008), The Kid with a Bike (2011), Saint Laurent (2014), The Unknown Girl (2016), Double Lover (2017), and Frankie (2019).
- Is the youngest child in his family and has two sisters and one brother.
- 2002: Named as one of European films' Shooting Stars by European Film Promotion.
- Often works with directors Jean-Pierre Dardenne and Luc Dardenne, François Ozon and Bertrand Bonello.
- Has starred in 3 movies with Marion Cotillard: Cavalcade (2005), Dikkenek (2006), and Fair Play (2006).
- He is an agnostic.
- Gained 25 kilos (around 55 pounds) for the film Possessions (2011).
- Companion of set decorator Laura Léonard since the mid-2010s.
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