New York, May 27 (Ians) Inhalable nanobodies targeting the spike protein of the Sars-CoV-2 coronavirus can prevent and treat severe Covid-19, according to a study in hamsters.
Researchers from the University of Pittsburgh in Pennsylvania, US, tested the nanobodies -- which are similar to monoclonal antibodies but smaller in size, more stable and cheaper to produce -- for inhalation treatment against coronavirus infections in a pre-clinical model.
The findings, published in the journal Science Advances, showed that low doses of an aerosolised nanobody named Pittsburgh inhalable Nanobody-21 (PiN-21) protected hamsters from the dramatic weight loss typically associated with severe Sars-CoV-2 infection. It also reduced the number of infectious virus particles in the animals' nasal cavities, throats and lungs by a million-fold, compared to placebo treatment with a nanobody that doesn't neutralise the virus.
"By using an inhalation therapy that can be directly administered to the infection site -- the respiratory tract and lungs,...
Researchers from the University of Pittsburgh in Pennsylvania, US, tested the nanobodies -- which are similar to monoclonal antibodies but smaller in size, more stable and cheaper to produce -- for inhalation treatment against coronavirus infections in a pre-clinical model.
The findings, published in the journal Science Advances, showed that low doses of an aerosolised nanobody named Pittsburgh inhalable Nanobody-21 (PiN-21) protected hamsters from the dramatic weight loss typically associated with severe Sars-CoV-2 infection. It also reduced the number of infectious virus particles in the animals' nasal cavities, throats and lungs by a million-fold, compared to placebo treatment with a nanobody that doesn't neutralise the virus.
"By using an inhalation therapy that can be directly administered to the infection site -- the respiratory tract and lungs,...
- 5/27/2021
- by Glamsham Bureau
- GlamSham
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